Polypeptides are polymers built from natural occurring building blocks, amino acids. In contrast to conventional peptides and proteins, We take profit of the architectural versatility of amino acids to build a plethora of functional polypeptides with potential applications in drug delivery and materials science. These biocompatible and biodegradable polymers offers unique advantages for drug delivery as they can be engineered for example, to carry a high cargo loading or to provide specific physico-chemical properties to allow bypassing biological barriers, allowing to enhance bioavailability or body residence times and hence, boosting the therapeutic activity